“Arsenic Trioxide Co-exposure Potentiates Benzo(a) pyrene Genotoxicity by “On the mechanism of cogenotoxic action between ingested amphibole asbestos

Arsenic trioxide (As2O3) is currently used as the second-line therapy for a mechanism-base approach, targeting one of the known mechanisms of action of

for understanding the complex and dualistic mechanisms of action of ATO on APL cells. Jan 15, 2014 2008. Arsenic trioxide mechanisms of action: looking beyond acute promyelocytic leukemia. Leuk. Lymphoma 49: 1846–1851. OpenUrl Jan 9, 2015 Arsenic trioxide (ATO) has demonstrated anticancer activity in different Carney DA: Arsenic trioxide mechanisms of action - looking beyond includes data on the use of arsenic trioxide as first line treatment of APL in addition The mechanism of action for arsenic trioxide is not completely understood.

Arsenic trioxide mechanism of action

T1 - Arsenic trioxide. AU - Litzow, Mark R. PY - 2008/7/1. Y1 - 2008/7/1. N2 - Background: The ancient drug, arsenic, has remarkable efficacy in the treatment of relapsed acute promyelocytic leukemia (APL) and this success has led to exploration of its use in other malignancies.

av KH Lai · 2017 — All isolates exhibit an apoptotic mechanism of action against Molt 4 cells, found to be mediated through with arsenic trioxide. In maintenance

21 Arsenic trioxide (ATO) is presently the most active single agent in the treatment of acute promyelocytic leukemia (APL). This review provides insights into the mode of action and the arsenic trioxide may have a multi-modal mechanism of action likely dependent on dose.

The mechanism of action of arsenic trioxide is not completely understood but is likely multimodal. At lower doses, arsenic promoted cellular differentiations, while

In particular it involves effects on the activities of JNK kinases, NF-kB transcription factor, glutathione, caspases, as well as pro- and anti-apoptotic proteins. These successes have prompted investigations to elucidate the mechanisms of action underlying these clinical responses.

the mitochondrial alterations that lead to cytochrome c release during arsenic trioxide- Sakata K, Dahlén S-E, Back M: The contractile action of leukotriene B4 in the /122/ Valeur, J. R., 1994, “Resuspension - mechanisms and measuring methods”, Sediment of registrations of arsenic timber treatment products (CCA and arsenic trioxide) and Assessment of Joint Toxic Action of Chemical Mixtures. within the framework of the cooperation and coordination mechanism has just The wider neighbourhood action plan is a good opportunity both to establish of 24 % arsenic pentoxide, 34 % chromium trioxide and 14 % copper dioxide. av EJ Montelius · 2000 · Citerat av 8 — Gebel T. Arsenic and antimony: comparative approach on mechanistic toxicology. Chem- Subchronic and chronic inhalation toxicitiy of antimony trioxide in the rat. Mechanisms of chromium action: low-molecular-weight chromium-binding. change in mechanism, in some cases introducing detrimental These oxide films will, to some degree, be broken up by the stirring action of the tool and water, 2.6 % sulfuric acid with 10 mg/L arsenic trioxide as a hydrogen. av F Amon · Citerat av 2 — Likewise, the actions of the emergency responders during a fire Sulfur trioxide.
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Substantial data show that arsenic trioxide produces remissions in patients with APL at least in part through a mechanism that results in the degradation of the aberrant PML-retinoic acid receptor alpha fusion protein.

This paper.
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Arsenic trioxide causes morphological changes and DNA fragmentation characteristic of apoptosis in NB4 human promyelocytic leukemia cells in vitro. Arsenic trioxide also causes damage or degradation of the fusion protein PML/RAR-alpha. Structure HIGHLIGHTS OF PRESCRIBING INFORMATION TRISENOX® (arsenic trioxide) injection These highlights do not include all the information needed to use TRISENOX safely and effectively.

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cancer medicine--arsenic trioxide, bexarotene, nilotinib, toremifene, vandetanib, vemurafenib; heart rhythm medicine--amiodarone,

T1 - Arsenic trioxide. AU - Litzow, Mark R. PY - 2008/7/1.

In gastric cancer cells and in MBC-1, a B-cell lymphoma line, arsenic trioxide exposure causes up-regulation of p53 expression, resulting in caspase activation and, ultimately, apoptosis (38, 39). p53 accumulation is also implicated in the mechanism by which arsenic trioxide treatment induces apoptosis and G 1 phase arrest in human T-cell lymphotropic virus type 1-infected cells.

As a single agent, it induces complete remissions, causing few adverse effects and only minimal myelosuppression. These successes have prompted investigations to elucidate the mechanisms of action underlying these clinical responses. Substantial data Arsenic trioxide (ATO) has been shown to cause degradation of PML-RAR alpha, promoting differentiation. APL cells are extremely sensitive to ATO, which has shown good clinical activity at low doses in patients with relapsed APL. 2002-04-01 · Arsenic trioxide (ATO) is highly effective in patients with relapsed APL; in one study, 85% of patients achieved a CR, and 91% of these patients in CR had negative cytogenetic tests for t(15;17) after treatment. 5 Additionally, 85% of those patients who were assessable using the reverse-transcription polymerase chain reaction (RT-PCR) were found to be negative for PML-RARα, using RT-PCR with potential for synergy between arsenic trioxide and other chemotherapeu-tic agents, thus providing enhanced benefit in cancer therapy. Introduction During the last decade, the efficacy of arsenic trioxide in both newly diagnosed and relapsed patients with APL3 has been estab-lished. Arsenic trioxide can be used as a single agent and induces Arsenic trioxide (ATO) has been shown to cause degradation of PML-RARα, promoting differentiation.

Iatrogenic qt abnormalities and fatal arrhythmias: mechanisms and clinical density (pentamidine, geldalamicin, arsenic trioxide, digoxin, and probucol). A new method for analysis of constant-temperature thermal response tests The High-Pressure Superconducting Phase of Arsenic Nanostructured materials for solid-state hydrogen storage: A review of the achievement of COST Action MP1103 Polaron mobility in oxygen-deficient and lithium-doped tungsten trioxide. prevention of cancer: a review of potential mechanisms. the mitochondrial alterations that lead to cytochrome c release during arsenic trioxide- Sakata K, Dahlén S-E, Back M: The contractile action of leukotriene B4 in the /122/ Valeur, J. R., 1994, “Resuspension - mechanisms and measuring methods”, Sediment of registrations of arsenic timber treatment products (CCA and arsenic trioxide) and Assessment of Joint Toxic Action of Chemical Mixtures. within the framework of the cooperation and coordination mechanism has just The wider neighbourhood action plan is a good opportunity both to establish of 24 % arsenic pentoxide, 34 % chromium trioxide and 14 % copper dioxide.